Best Cold And Flu Medicine For Adults Non Drowsy In June 2025

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If you are ready to choose a new Best Cold And Flu Medicine For Adults Non Drowsy, check out our detailed recommendation below!.

To help you in your search, we have completed this list of the Best Cold And Flu Medicine For Adults Non Drowsy.

Top Rated Best Cold And Flu Medicine For Adults Non Drowsy Of 2025

Rank Product Name Score
1
Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24
Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24
9.7
2
Boiron Coldcalm, 60 Tablets, Homeopathic Medicine for Cold Relief
Boiron Coldcalm, 60 Tablets, Homeopathic Medicine for Cold Relief
9.5
3
Vicks DayQuil Cold and Flu Multi-Symptom Relief, 48 LiquiCaps (Non-Drowsy) - Sore Throat
Vicks DayQuil Cold and Flu Multi-Symptom Relief, 48 LiquiCaps (Non-Drowsy) - Sore Throat
9.1
4
Basic Care Cold & Flu Relief Multi-Symptom Daytime/Nighttime Combo Pack Softgels, 48 Count
Basic Care Cold & Flu Relief Multi-Symptom Daytime/Nighttime Combo Pack Softgels, 48 Count
8.8
5
Sudafed PE Sinus Congestion Maximum Strength Non-Drowsy Decongestant Tablets, 36 ct
Sudafed PE Sinus Congestion Maximum Strength Non-Drowsy Decongestant Tablets, 36 ct
8.6
6
Vicks DayQuil and NyQuil SEVERE Cough, Cold and Flu Relief, 48 LiquiCaps
Vicks DayQuil and NyQuil SEVERE Cough, Cold and Flu Relief, 48 LiquiCaps
8.3
7
Coricidin HBP Decongestant-Free Cough and Cold Medicine for Hypertensives, Cold Symptom Relief
Coricidin HBP Decongestant-Free Cough and Cold Medicine for Hypertensives, Cold Symptom Relief
8.1
8
Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Powermax Liquid Gels
Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Powermax Liquid Gels
7.8
9
Nature's Way Umcka Cold+Flu Multi-Action Non-Drowsy Relief, Fructose-Free Syrup, 99.95% Alcohol Free, Berry
Nature's Way Umcka Cold+Flu Multi-Action Non-Drowsy Relief, Fructose-Free Syrup, 99.95% Alcohol Free, Berry
7.5
10
Medique Products 82233 Cold Relief Tablets, 100 Tablets
Medique Products 82233 Cold Relief Tablets, 100 Tablets
7.2

1. Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24

1
9.7/10 our score

  • From the #1 doctor-recommended pain relief brand, these sinus relief caplets are suitable for adults and children ages 12 years and older
  • Each caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever as well as 5 mg of phenylephrine hcl, a nasal decongestant to help clear nasal passages
  • 24-count box of tylenol sinus + headache daytime caplets for non-drowsy sinus symptom relief due to the common cold, hay fever or other respiratory allergies
  • Pain reliever and decongestant formulated to temporarily relieve symptoms of nasal congestion, sinus headache and pressure
  • The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages

2. Boiron Coldcalm, 60 Tablets, Homeopathic Medicine for Cold Relief

2
9.5/10 our score

  • Recommended for everyone ages 3 and up, andis available in a box of 60 quick-dissolving tablets.
  • At boiron, we believe theres more than one way to feel better. since 1932, the boiron family has been committed to providing quality medicines. as world leader in homeopathy, our passion is your health. our promise is your satisfaction.
  • Coldcalm tablets address symptoms at every stage of a cold. it temporarily relieves symptoms such as sneezing, runny nose, nasal congestion and minor sore throat.
  • Coldcalm tablets do not cause drowsiness and it has no known interactions with other medications.
  • Boiron cough, cold and flu medicines do not cause drowsiness or sleeplessness

3. Vicks DayQuil Cold and Flu Multi-Symptom Relief, 48 LiquiCaps (Non-Drowsy) - Sore Throat

3
9.1/10 our score

  • Multi-symptom relief. dayquil cold & flu contains an expectorant to help loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive
  • #1 pharmacist recommended over-the-counter cold & cough medicine from vicks, the worlds #1 selling cough & cold brand
  • Active ingredients: acetaminophen 325mg, dextromethorphan hbr 10mg, phenylephrine hcl 5mg, do not refrigerate
  • Non-drowsy, daytime relief. dayquil cold & flu liquicaps help you get your power back so you can enjoy the day
  • Non-drowsy.
  • Powerful 6-symptom relief. temporarily relieves common cold & flu symptoms, including nasal congestion, cough due to minor throat and bronchial irritation, sore throat, headache, minor aches & pains, and fever

4. Basic Care Cold & Flu Relief Multi-Symptom Daytime/Nighttime Combo Pack Softgels, 48 Count

4
8.8/10 our score

  • Cold and flu symptoms: influenza (flu) and the common cold are respiratory illnesses caused by viruses. the cold has a gradual onset of symptoms, such as cough, sore throat and runny or stuffy nose. the flu has a sudden onset of symptoms, such as a fever over 100.4f, headache, nasal congestion, sore throat, fatigue and weakness, chills and sweats, and aching muscles, e...
  • Active ingredients: daytime cold & flu relief contains acetaminophen (pain reliever/fever reducer), dextromethorphan hbr (cough suppressant) and phenylephrine hcl (nasal decongestant) which compares to the active ingredients in vicks dayquil cold & flu. nighttime cold & flu relief contains acetaminophen (pain reliever/fever reducer), dextromethorphan hbr (cough suppre...
  • Nighttime cold and flu medicine provides multi-symptom relief of headache, fever, sore throat, sneezing, runny nose, cough, and minor aches and pains.
  • Pain reliever and fever reducer: both daytime and nighttime cold medicine contain acetaminophen to help relieve aches, fever and sore throat.
  • Non-drowsy daytime cold and flu medicine provides multi-symptom relief of headache, fever, sore throat, nasal congestion, cough, and minor aches and pains.

5. Sudafed PE Sinus Congestion Maximum Strength Non-Drowsy Decongestant Tablets, 36 ct

5
8.6/10 our score

  • Each coated tablet contains 10 milligrams of phenylephrine hcl, a nasal decongestant that provides non-drowsy symptom relief
  • From the #1 pharmacist recommended brand among oral otc decongestants, this non-drowsy decongestant can be used by adults and children 12 years and older for fast, powerful relief
  • This sinus congestion & pressure relief medicine also helps reduce nasal swelling to help you breathe easier, and can be taken every 4 hours as necessary for effective relief of cold and allergy symptoms
  • The maximum strength formula helps clear sinus congestion and relieve sinus pressure due to the common cold, hay fever or other upper respiratory allergies
  • 36-count of sudafed pe sinus congestion maximum strength non-drowsy tablets for fast, powerful relief of sinus pressure and sinus and nasal congestion

6. Vicks DayQuil and NyQuil SEVERE Cough, Cold and Flu Relief, 48 LiquiCaps

6
8.3/10 our score

  • Our smallest most powerful nighttime liquicap. nyquil severe relieves your sneezing, sore throat, headache, minor aches & pains, fever, runny nose, and cough, so you can get the rest you need
  • Multi-symptom relief with nyquil severe cold & flu, which also contains a nasal decongestant and dayquil severe cold & flu, which contains an expectorant to help loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive
  • Maximum strength cold & flu relief. dayquil/nyquil severe delivers maximum symptom-fighting ingredients to relieve your worst cold & flu symptoms, such as cough, sore throat, fever, and congestion, day or night
  • Pain relief & fever reducer. dayquil/nyquil severe is an over-the-counter medicine that contains acetaminophen, a pain reliever and fever reducer that can help soothe sore throat
  • Smallest branded, 4-active, maximum strength daytime liquicaps. dayquil severe offers non-drowsy relief of your cold and flu symptoms, so you can power through your day

7. Coricidin HBP Decongestant-Free Cough and Cold Medicine for Hypertensives, Cold Symptom Relief

7
8.1/10 our score

  • Bayer consumer care
  • Decongestant-free cold relief for people with high blood pressure
  • Provides fast, powerful cold relief for people with high blood pressure
  • The #1 brand that gives powerful cold symptom relief without raising your blood pressure
  • Decongestant free
  • Relieves cough, runny nose, and sneezing

8. Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Powermax Liquid Gels

8
7.8/10 our score

  • Covered by bayer healthcare llc-consumer health 60-day satisfaction guarantee.
  • Day time multi-symptom relief of nasal congestion, cough, headache, body ache, sore throat, sinus pressure and fever. night time multi-symptom relief of runny nose, nasal congestion, cough, headache, body ache, sore throat and fever.
  • Maximum strength day time and night time relief from your worst cold & flu symptoms
  • Fast relief so you can get back to your busy life. use as directed.
  • 25% smaller pill: alka-seltzer plus maximum strength cold & flu powermax gels have a concentrated formula to provide powerful fast relief

9. Nature's Way Umcka Cold+Flu Multi-Action Non-Drowsy Relief, Fructose-Free Syrup, 99.95% Alcohol

9
7.5/10 our score

  • Traditional roots: umcka is made from pelargonium sidoides roots and originates from traditional south african medicine
  • Works differently: umcka does more than just relieve common cold and cough symptoms - it actually speeds your recovery time
  • Clinically proven: umcka (pelargonium sidoides 1x) is proven effective in clinical studies for alleviating common colds plus nasal, throat and bronchial irritations
  • Shortens duration and reduces severity: cough,congestion,hoarseness, sore throat, sneezing and stuffy/runny nose
  • Great tasting: berry flavored. quickly absorbed soothing syrup. non- drowsy, suitable for children

10. Medique Products 82233 Cold Relief Tablets, 100 Tablets

10
7.2/10 our score

  • Easy dispensing box
  • Each box contains 50 packets, 2 pills per packet
  • Each tablet contains acetaminophen 325mg, guaifenesin 200mg, phenylephrine hci 5mg and dextromethorphan habra 15mg
  • Individual tamper evident packets
  • Non-drowsy, fast-acting, multi-symptom formula

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