Best Natural Supplement For Depression In May 2025

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In this article, we will present the top 10 Best Natural Supplement For Depression available on the market, along with our expert reviews. Get one of them and have fun! You’ll love it!

To help you in your search, we have completed this list of the Best Natural Supplement For Depression.

Top Rated Best Natural Supplement For Depression Of 2025

Rank	Product Name	Score
1	Joy-Filled | 100% Plant-Based Supplement for Anxiety & Depression Relief | Helps Relax Buy Now	9.7 Buy Now
2	Zen Anxiety and Stress Relief Supplement - Natural Herbal Formula Supporting Calm, Positive Buy Now	9.5 Buy Now
3	Happy Pills Natural Anti Anxiety Relief & Depression Supplement | Dopamine Mood Boost Buy Now	9.1 Buy Now
4	200 MG 5-HTP Plus Serotonin Synthesizers and Cofactor B6 for Improved Serotonin Conversion Buy Now	8.8 Buy Now
5	Ashwagandha 1300mg Made with Organic Ashwagandha Root Powder & Black Pepper Extract Buy Now	8.6 Buy Now
6	Anti Anxiety Relief and Depression Supplement - Natural Stress Support & Serotonin Mood Buy Now	8.3 Buy Now
7	St.John's Wort 900mg Supplement-Natural Antidepressant for Mood Boost, Anxiety & Depression Support-Provides Extended Buy Now	8.1 Buy Now
8	Brain Support Supplement Formula - Booster Memory, Clarity Serotonin Levels, and Mood Buy Now	7.8 Buy Now
9	TransZen | Natural Supplement - Depression & Anxiety | Boost Your Mood Buy Now	7.5 Buy Now
10	Probiotic - Mood Super Strains - Psychobiotic for Anxiety and Depression - Histamine-Free Buy Now	7.2 Buy Now

1. Joy-Filled | 100% Plant-Based Supplement for Anxiety & Depression Relief | Helps Relax

• Relieves depression and boosts mood: the collection of herbs works harmoniously together to act as an anti depressant and help you maintain a stable and positive mood. st johns wort works to increase the availability of the chemicals serotonin, dopamine, and norepinephrine in the brain, which are crucial components in maintaining a positive state of mind.
• Consists of 7 powerful herbs: these 7 healing herbs have been used for centuries and are considered to be a mood enhancer that provides natural anxiety relief and act as a natural antidepressant. the dosage of each herb included has been scientifically proven to be effective. we do not believe in the concept of "fairy dusting", which is when a tiny amount of a herb or n...
• Anxiety relief and stress relief: the herbs included help to increase the production of gaba, a key neurotransmitter that works to reduce restlessness and promote an overall calming effect. other herbs such as rhodiola rosea and gingko biloba supports a healthy response to stress by decreasing the cortisol levels in your body and by calming the sympathetic nervous system.
• 100 percent plant-based: completely plant-based anxiety supplement and depression supplements that provides total mood support. your brain and body may need a little extra nutritional support to help with anxiety, depression, and stress. we at happy healthy hippie have found that absorbing very specific nutrients can be the key in getting your mind and body the relief t...
• Customer friendly: we truly appreciate each of you and are grateful to have you as customers. if our product doesn't meet your needs in the way you had hoped, we have a 60-day easy return policy. our product is formulated and created in a fda registered us facility that is certified under strict good manufacturing practice standards by two certifying agencies.

2. Zen Anxiety and Stress Relief Supplement - Natural Herbal Formula Supporting Calm, Positive

• Were a brand you can trust - publications such as vogue, glamour, mens fitness, and the new york times have endorsed wellpath as a highly-trusted, thoroughly vetted and dependable provider of wellness supplements and personal nutrition. wellpath is backed by an extensive community of experts across a wide range of fields who unanimously support wellpaths truly...
• Stay focused and upbeat - its not always easy to be social, remain relaxed, or act positive. we combined high quality, natural mood enhancers like passion flower and niacinamide powder with energy-supporting riboflavin and magnesium, to help sharpen your mind and improve your positive energy throughout the day. we created wellpath zen with your calmest, brightes...
• Live with ease | premium stress and anxiety support - do you ever feel overwhelmed, frazzled, or paralyzed by anxiety? youre not the only one in this hectic modern life. we know the feeling, and dont like it one bit, which is why we created wellpath zen. our premium wellpath zen formula was expertly curated to contain the optimal natural mix of adaptogens, herb...
• Safety & quality are our top priority - wellpath prides itself on delivering vitamins and supplements at the highest degree of quality while also being completely safe for all consumers. wellpath zen is entirely non-gmo, gluten free, and soy free in an all veggie capsule. our product is manufactured in a gmp-certified and fda-registered facility, and is proudly m...
• Natural herbal ingredient formula - wellpath zens calming formula comprises ingredients that are natural, handpicked by experts, and refined to support stress management and promote a natural sense of well-being. our formula features ashwagandha, an ayurvedic herb known to reduce stress, rhodiola rosea, a scandinavian adaptogen famed for increasing energy levels...

3. Happy Pills Natural Anti Anxiety Relief & Depression Supplement | Dopamine Mood Boost

• 7 powerful organic herbs: 7 healing herbs have been used for centuries and are considered to be a mood enhancer that provides natural anxiety relief and act as a natural antidepressant. these herbs are gotu kola herb, rhodiola root, st. john's wort herb, ashwagandha root, lemon balm leaf, ginkgo leaf, and eleuthero root. the dosage of each included herb has been scienti...
• Natural organic non-gmo plant-based herbs: plant-based anxiety supplement and depression supplements that provides total mood support. your brain and body may need a little extra nutritional support to help with anxiety, depression, and stress. absorbing very specific nutrients can be the key in getting your mind and body the relief that it needs.
• Your happiness is important: if our product doesn't meet your needs in the way you had hoped, we have a 100% satisfaction guarantee refund policy. our product is made in the usa and manufactured in an fda and gmp approved facility.
• Anxiety relief and stress relief: the herbs included help increase the production of gaba, a key neurotransmitter that works to reduce restlessness and promote an overall calming effect. other herbs such as rhodiola rosea and gingko biloba supports a healthy response to stress by decreasing the cortisol levels in your body and by calming the sympathetic nervous system.
• Relieves depression & boosts mood: the collection of herbs works harmoniously together to act as an anti depressant and help you maintain a stable and positive mood. st johns wort works to increase the availability of the chemicals serotonin, dopamine, and norepinephrine in the brain, which are crucial components in maintaining a feel good positive state of mind.

4. 200 MG 5-HTP Plus Serotonin Synthesizers and Cofactor B6 for Improved Serotonin Conversion

• Only the right stuff - all dr. emil products are made from all-natural vitamins, minerals & herbal extracts, without the use of harmful additives, non-gmo, free of gluten and all top 8 allergens. all products are manufactured in the usa in an fda-registered, gmp certified laboratory.
• 5-htp enhanced super formula - we supplemented 200mg of pure 5-htp with clinically proven serotonin synthesizers, same and l tryptophan. tryptophan is metabolized into 5-htp in the body, while same is a well-known serotonin booster. in addition, both ingredients have been indicated to help 5-htp conversion to serotonin, creating the ideal synergistic mood booster.
• Mood, anxiety & sleep support - 5-htp is the primary precursor to serotonin production in the body. increased levels of serotonin have been scientifically shown to promote positive mood, anxiety relief and better sleep.
• Doctor-driven, science backed - bringing dr. emils unique knowledge as both a medical doctor & recognized authority in the supplementation field, our blends are painstakingly formulated to provide superior results and are always backed by science - free of gimmicks, fads & false promises.
• B6 for improved serotonin conversion - our formula includes a high dosage of vitamin b6, the main co-factor necessary to convert 5-htp into serotonin. vitamin b6 has been clinically shown to aid 5-htp conversion into serotonin, while even slight b6 deficiency can greatly inhibit the efficacy of 5-htp.

5. Ashwagandha 1300mg Made with Organic Ashwagandha Root Powder & Black Pepper Extract

• Superior immune boost, hormonal balance & mood support: because our ashwagandha powder is sourced from organic ashwagandha root, it delivers the optimum concentration of withanolides to stimulate adaptogenic activity and optimize adrenal health, stress relief and thyroid support. more potent than other ashwagandha supplements, ashwagandha oil and ashwagandha tincture, i...
• 1300mg - highest potency for best anti-stress & anti-anxiety support: made with 100% organic ashwagandha root powder and organic black pepper extract for increased absorption, our pure ashwagandha capsules offers the most potent formula in the market (1300mg per serving) to deliver superior anti-stress, anti-anxiety and adrenal support*
• No fillers - no binders - no allergens - no heavy metals: our ashwagandha root capsules are free of fillers, binders, nuts, eggs, shellfish and other common allergens. in addition, testing is performed after every critical stage of production to ensure our products are free of adulterants, solvent residues, aflatoxins, microbiological pathogens and heavy metals such as ...
• 100% money back guarantee: at nutririse, we care about your experience. in fact we are so confident that you will love our premium ashwagandha that we back it with a 90-day money back guarantee. our ashwagandha supplement is proudly encapsulated in a fda-registered facility in the usa according to stringent gmp regulations. each and every batch is independently and thir...
• Made with certified organic ashwagandha root powder: in order to ensure an ashwagandha supplement is truly organic, it must be certified by an accredited certifying agent. made with organic ashwagandha extract, our natural ashwagandha supplement is certified organic by udaf*

6. Anti Anxiety Relief and Depression Supplement - Natural Stress Support & Serotonin Mood

• Positive mood and clearer mind: everyone deals with some sort ofstress in their life. from commuting to work, getting the kids ready for the day, running late to an appointment and on and on, pure bliss helps you look at these stressful situations with a clearer mind and a more positive outlook.
• Non-habit forming: created using only ancient herbs and vitamins that are proven and not habit forming, pure bliss does not contain any herbs that may make you drowsy like otheranxiety relief supplements do. use pure bliss with confidence knowing you are getting the highest quality herbs to help relievestress,anxiety and depression.
• 60 day satisfaction guarantee: if you are on the fence about trying pure bliss, dont be. we want you to totally confident when you buy from us. if you do not feel like it works for you or you are unhappy for any reason, let us know and we will issue a full refund within 60 days. no questions asked!
• Find relief fromstress and anxiety: over 70% of americans suffer from physical or emotional symptoms caused bystress. our all naturalanxiety andstress relief supplement was created to help you put a stop to these symptoms, and go through life with a glass-half-full attitude. using earth grown herbs and vitamins, our formula helps to promote a more balanced mood, s...
• All natural depression support: the formula of pure bliss was vetted by experts in the field to find select adaptogenic herbs that helps our body find its natural balance. adaptogenic herbs like ashwagandha, rhodiola, eleuthero root, which are paired with lemon balm leaf, gotu kola, ginkgo and l-theanine make the perfect combo to support a naturally balanced and uplif...

7. St.John's Wort 900mg Supplement-Natural Antidepressant for Mood Boost, Anxiety & Depression

• Recommended dose by scientific studies 900 mg - clinical trials evaluating the potency of st. john's wort in depression have proved that the best results are achieved with 900 mg per day. blossom nature's 1 capsule of 450 mg taken twice a day provide the full clinical dose to relieve symptoms of depression and anxiety for 24 hours with no side effects.
• Quality and safety - blossom nature's st. johns wort is non-gmo, vegan, gluten free. it is manufactured in gmp facility in the usa. each bottle includes 120 capsules for a full 2 month supply of highest quality st. johns wort.
• Natural mental wellness support - for centuries, the flowering plant st. john's wort was used as a health remedy in europe. today st. john's wort is best known as a treatment for depression, anxiety and stress. st. john's wort effective as prescribed antidepressants but with no side effects.
• Emotional wellness - st. johns wort is a natural treatment for mental health problems. it contains 0.3% (2.7mg) of hypericin per serving. hypericin is the most important natural compound that increases the level of serotonin, hormone of happiness. st. john's wort boosts mood, moderates seasonal affective disorder (sad), promotes a good night's sleep, relieves pms sympt...
• Money back guarantee - 30 days unconditional money back guarantee. we want you to be fully satisfied. if st. johns wort does not work for you, please send it back and get your money back.

8. Brain Support Supplement Formula - Booster Memory, Clarity Serotonin Levels, and Mood

• Quality assurance - we take pride in providing quality products which are made in the usa for our amazing customers. if you arent satisfied with our products for any reason, please contact us immediately and we will do whatever it takes to make you happy!
• Overall brain health and cognition enhancer!* the combination of vitamins and minerals in these once-per-day pills provide natural support for both men and women who may experience brain fog, difficulties with concentration, memory lapses, adhd, reduced energy, reduced sex drive, mild depression, sleep disturbances*, or used as a supplement to antidepressants, ssris, o...
• All natural, gluten free, no gmo -- dairy free, soy free, no hormones, no antibiotics, no preservatives, no yeast, no soy, no sugar, no cholesterol, no artificial colors/flavors, no binders, no fillers, 3rd party tested, and made in the usa.
• Mood, stress and immunity support! re-energize your mind and mental abilities. this specifically formulated supplement can booster your brain and bodys ability to decrease anxiety leading to better mental health without any of the jittery side effects you get from caffeine or other stimulants.* let our anti-brain-fog formula help you experience all the joy life has to ...
• Brain support our brain support may help boost all areas of memory functions, including working memory and recall. our blend of non-stimulating vitamins and minerals can help to promote better concentration.

9. TransZen | Natural Supplement - Depression & Anxiety | Boost Your Mood

• Quality assurance - this product is manufactured in the usa in a facility that is certified by the fda as having gmp standards (good manufacturing practices). transzen doesnt contain the controversial ingredients magnesium stearate or silicone dioxide commonly found in other supplements. analysis is done to confirm purity and cleanliness of ingredients.
• All natural alternative to conventional treatments - transzen improves your mood naturally without the uncomfortable, common side effects you may experience from other products.
• Feel happy & calm - are feelings of stress, anxiety and depression sucking the joy out of your life? nutrient deficiency and oxidative stress can leave you with feeling down. nourish your brain with essential vitamins, amino acids and herbs.
• Boosts energy and sleep - by balancing your brain and nervous system with tranzen, you can experience increased energy and mental alertness, as well as more restful, deeper sleep.
• Scientifically studied ingredients - all ingredients in tranzen have been subjected to extensive scientific research and are generally regarded as safe (gras) by the fda.

10. Probiotic - Mood Super Strains - Psychobiotic for Anxiety and Depression - Histamine-Free

• Just probiotics. no prebiotics. no fillers. no added ingredients
• Targeted super strains: top clinically studied strains including l. rhamnosus gg ( for depression and anxiety) and b. longum ( for depression).
• High quality and shelf stable. this sensitive formula ensures healthy digestion, immunity and mental health. no refrigeration required!
• 60 capsules per bottle -- a two month supply!
• D-lactate free & histamine free. 30 billion cfu with key strains for mood and digestion make it a high potency probiotic... offering digestive, immune, and mental support