Best Sinus Medicine For Adults In July 2025

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In this article, we will present the top 10 Best Sinus Medicine For Adults available on the market, along with our expert reviews. Get one of them and have fun! You’ll love it!

To help you in your search, we have completed this list of the Best Sinus Medicine For Adults.

Top Rated Best Sinus Medicine For Adults Of 2025

Rank	Product Name	Score
1	Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24 Buy Now	9.7 Buy Now
2	Flonase Nasal Spray for Allergy Relief, 24-Hour Non-Drowsy Allergy Medicine, 120 Sprays Buy Now	9.5 Buy Now
3	Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant, 24 ct Buy Now	9.1 Buy Now
4	Sudafed PE Sinus Congestion Maximum Strength Non-Drowsy Decongestant Tablets, 36 ct Buy Now	8.8 Buy Now
5	Alka-Seltzer Plus Maximum Strength Powermax Liquid Gels, Severe Sinus, Allergy & Cough, 24 Buy Now	8.6 Buy Now
6	Allegra Adult 24 Hour Allergy Relief 70-Count Long-Lasting Fast-Acting Antihistamine for Noticeable Relief Buy Now	8.3 Buy Now
7	GoodSense Maximum Strength Nasal Decongestant PE, Phenylephrine HCl, 10 mg tablets. Nasal Buy Now	8.1 Buy Now
8	Mucinex Sinus-Max Max Strength Day & Night Caplets 20 ct Buy Now	7.8 Buy Now
9	Zyrtec 24 Hour Allergy Relief Tablets, 10 mg Cetirizine HCl Antihistamine Allergy Medicine Buy Now	7.5 Buy Now
10	Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Tablets, 20 ct Buy Now	7.2 Buy Now

1. Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24

• Each caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever as well as 5 mg of phenylephrine hcl, a nasal decongestant to help clear nasal passages
• From the #1 doctor-recommended pain relief brand, these sinus relief caplets are suitable for adults and children ages 12 years and older
• Pain reliever and decongestant formulated to temporarily relieve symptoms of nasal congestion, sinus headache and pressure
• 24-count box of tylenol sinus + headache daytime caplets for non-drowsy sinus symptom relief due to the common cold, hay fever or other respiratory allergies
• The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages

2. Flonase Nasal Spray for Allergy Relief, 24-Hour Non-Drowsy Allergy Medicine, 120 Sprays

• Use nose spray once daily throughout allergy season for continuous relief
• Flonase allergy relief is the number 1 doctor recommended allergy brand (among over the counter (otc)) allergy medications based on physicians survey dated 6/23/17)
• Contains the active ingredient fluticasone propionate
• Flonase nose spray allergy medicine relieves nasal congestion, runny nose, sneezing, itchy nose, and itchy, watery eyes
• Full prescription strength flonase nasal spray provides non drowsy, 24 hour relief

3. Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant, 24 ct

• The non-drowsy decongestant helps promotes sinus drainage, temporarily reduces fever and helps relieve headaches and minor aches and pain
• This sinus congestion & pain medicine also temporarily relieves nasal congestion associated with hay fever, upper respiratory allergies and the common cold
• From the #1 pharmacist recommended brand among oral otc decongestants, this maximum strength formula can be used by adults and children 12 years and older for powerful symptom relief
• Each caplet contains 5 milligrams of the decongestant phenylephrine hcl and 325 milligrams of acetaminophen, a pain reliever and fever reducer
• 24-count box of sudafed pe sinus pressure + pain relief maximum strength non-drowsy decongestant tablets provide powerful relief of sinus pain, sinus pressure, nasal congestion and headaches

4. Sudafed PE Sinus Congestion Maximum Strength Non-Drowsy Decongestant Tablets, 36 ct

• From the #1 pharmacist recommended brand among oral otc decongestants, this non-drowsy decongestant can be used by adults and children 12 years and older for fast, powerful relief
• The maximum strength formula helps clear sinus congestion and relieve sinus pressure due to the common cold, hay fever or other upper respiratory allergies
• 36-count of sudafed pe sinus congestion maximum strength non-drowsy tablets for fast, powerful relief of sinus pressure and sinus and nasal congestion
• This sinus congestion & pressure relief medicine also helps reduce nasal swelling to help you breathe easier, and can be taken every 4 hours as necessary for effective relief of cold and allergy symptoms
• Each coated tablet contains 10 milligrams of phenylephrine hcl, a nasal decongestant that provides non-drowsy symptom relief

5. Alka-Seltzer Plus Maximum Strength Powermax Liquid Gels, Severe Sinus, Allergy & Cough, 24

• Covered by bayer healthcare llc-consumer health 60-day satisfaction guarantee.
• Fast relief so you can get back to your busy life. use as directed.
• New 25% smaller pill: alka-seltzer plus maximum strength severe sinus, allergy & cough powermax gels have a concentrated formula to provide powerful fast relief
• Powerful, multi-symptom relief for your worst allergies, including sinus congestion, headache, sneezing, cough, sinus pressure, runny nose, and itchy, watery eyes
• Get the fast , effective allergy symptom relief you need, when you need it

6. Allegra Adult 24 Hour Allergy Relief 70-Count Long-Lasting Fast-Acting Antihistamine for Noticeable

• Includes: one 70-count bottle of allegra adult non-drowsy antihistamine tablets for 24-hour allergy relief
• Indoor & outdoor allergies: use allegra tablets for indoor and outdoor allergies, including seasonal allergies and pet allergies
• 24-hour relief: one pill is all you need for round-the-clock relief from your worst allergy symptoms
• Non-drowsy: formulated with active ingredient fexofenadine, a non-drowsy antihistamine
• Fast-acting: allegra 24-hour allergy starts working in one hour for fast relief from sneezing, runny nose, itchy and watery eyes, and itchy nose or throat

7. GoodSense Maximum Strength Nasal Decongestant PE, Phenylephrine HCl, 10 mg tablets. Nasal

• How cold and flu spreads: most experts believe that cold and flu viruses are spread by respiratory droplets propelled when people with cold or flu cough, sneeze or talk.
• Uses: temporarily relieves sinus congestion and pressure, temporarily relieves nasal congestion due to the common cold, hay fever or other upper respiratory allergies
• Active ingredient: the active ingredient in nasal decongestant pe is phenylephrine hcl 10 mg, in each tablet, compare to sudafed pe congestion active ingredient.
• Common cold: a cold usually includes a runny nose, sore throat, sneezing, and coughing. these symptoms can last for up to two weeks.
• Flu: influenza (flu) is a contagious respiratory illness caused by influenza viruses infecting the nose, throat and lungs. it can cause mild to severe illness.

8. Mucinex Sinus-Max Max Strength Day & Night Caplets 20 ct

• Day time: relieves sinus pressure, congestion, headache, and thins and loosens mucus
• Maximum strength formula
• Night time: relieves nasal congestion, sinus pressure, pain, runny nose, sneezing, and controls cough
• 20 count (12ct day time caplets, 8ct night time caplets)

9. Zyrtec 24 Hour Allergy Relief Tablets, 10 mg Cetirizine HCl Antihistamine Allergy Medicine

• This powerful antihistamine contains 10 mg of cetirizine hydrochloride in each anti-allergy tablet and effectively treats indoor allergies caused by dust, mold, and pet dander, as well as outdoor allergies caused by tree pollen, weeds, and grasses
• Get effective allergy relief caused by hay fever and other upper respiratory allergies from the #1 allergist-recommended brand among over the counter oral antihistamines
• Suitable for those 6 years of age and older, this anti-allergy medicine provides powerful, effective relief for a full 24 hours in just a single dose
• These prescription-strength allergy medicine work fast and stay strong by providing all-day allergy relief that starts working hard at hour one and works twice as hard when taken again the next day
• 45-count bottle of zyrtec 24 hour allergy relief tablets for powerful relief of your worst indoor and outdoor allergy symptoms, including runny nose, sneezing, itchy, watery eyes, and itchy nose and throat

10. Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Tablets, 20 ct

• Each daytime and nighttime dose contains 10 milligrams of the nasal decongestant phenylephrine hcl and each nighttime dose also contains 25 milligrams of the antihistamine diphenhydramine hcl
• From the #1 pharmacist recommended brand among oral otc decongestants, this maximum-strength formula can be used by adults and children 12 years and older for powerful relief
• Both formulas help relieve sinus pressure and sinus congestion, and nasal congestion due to the common cold, hay fever, or upper respiratory allergies. nighttime tablets also relieve sneezing, runny nose, itchy, watery eyes and itchy throat or nose.
• 20-count of sudafed pe sinus congestion day + night maximum strength decongestant tablets to temporarily relieve sinus pressure and sinus congestion for both day and night
• Each multi-pack contains 20 tablets of nasal decongestant, with 12 daytime and 8 nighttime tablets for powerful symptom relief throughout the day and while you sleep