Best Enzyme Sprays In July 2025

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Choosing the Best Enzyme Spraysmay be challenging as you have to screen through the large amount of similar products available on the market. Don’t worry though; we have got our hands on 10 trendy and top rated products and below is our recommendation.

To help you in your search, we have completed this list of the Best Enzyme Sprays.

Top Rated Best Enzyme Sprays Of 2025

Rank Product Name Score
1
Rocco & Roxie Supply Professional Strength Stain and Odor Eliminator, Enzyme-Powered Pet Odor
Rocco & Roxie Supply Professional Strength Stain and Odor Eliminator, Enzyme-Powered Pet Odor
9.7
2
TriNova Natural Pet Stain and Odor Remover Eliminator - Advanced Enzyme Cleaner Spray
TriNova Natural Pet Stain and Odor Remover Eliminator - Advanced Enzyme Cleaner Spray
9.5
3
ANGRY ORANGE 24 oz Ready-to-Use Citrus Pet Odor Eliminator Pet Spray - Urine
ANGRY ORANGE 24 oz Ready-to-Use Citrus Pet Odor Eliminator Pet Spray - Urine
9.1
4
ANGRY ORANGE - Best Enzyme Pet Odor Eliminator and Stain Remover to Destroy
ANGRY ORANGE - Best Enzyme Pet Odor Eliminator and Stain Remover to Destroy
8.8
5
Puracy Natural Laundry Stain Remover, Enzyme-Based Spot Cleaner, Free & Clear, 25 Ounce
Puracy Natural Laundry Stain Remover, Enzyme-Based Spot Cleaner, Free & Clear, 25 Ounce
8.6
6
Simple Solution Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X
Simple Solution Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X
8.3
7
Nature’s Miracle P-96992 Advanced Stain and Odor Eliminator Cat, For Severe Cat Messes
Nature’s Miracle P-96992 Advanced Stain and Odor Eliminator Cat, For Severe Cat Messes
8.1
8
Nature's Miracle New Formula Stain & Odor Remover Spray, 32 fl. oz., 32
Nature's Miracle New Formula Stain & Odor Remover Spray, 32 fl. oz., 32
7.8
9
BUBBAS Super Strength Commercial Enzyme Cleaner - Pet Odor Eliminator | Enzymatic Stain
BUBBAS Super Strength Commercial Enzyme Cleaner - Pet Odor Eliminator | Enzymatic Stain
7.5
10
Woolite Advanced Pet Stain & Odor Remover + Sanitize, 2618, 22oz
Woolite Advanced Pet Stain & Odor Remover + Sanitize, 2618, 22oz
7.2

1. Rocco & Roxie Supply Professional Strength Stain and Odor Eliminator, Enzyme-Powered Pet Odor

1
9.7/10 our score

  • Enzyme activated the key is getting to the problem deep-down. this spray contains natural enzymatic bacteria that are activated on contact with odors and stains, feeding on ammonia crystals and organic matter until they are completely eliminated.
  • Certified gentle and safe chlorine free and color safe. safe to use around pets and children. no hazardous propellants, no residue left behind. so gentle its been certified safe for all carpets, earning the seal of approval by the trusted carpet and rug institute (cri)
  • Every surface, every time for use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas -- anywhere stains happen.
  • Eliminates stains, odors and residue if its gross, its gone. not just the stain, but the stink. from stinky yellow pet urine and feces to vomit and other organic spills, our professional strength formula tackles them all.
  • 100% satisfaction guaranteed an amazon best seller for a reason. if your stains and odors arent gone, neither is your money. well refund it in full

2. TriNova Natural Pet Stain and Odor Remover Eliminator - Advanced Enzyme Cleaner Spray

2
9.5/10 our score

  • Professional strength - trinova's pet stain & odor remover features a blend of natural enzymes that tackle stains and odors at their root to clean and neutralize. the enzymes work to break down the stains, drying out and disintegrating when they're finished to restore your carpet to like-new condition.
  • 100% natural cleaner - we are setting the "green standard' by using only natural and organic ingredients in our formula and listing everything right on the label.
  • Use it anywhere - use this natural pet stain remover on most surfaces such as bedding, mattress, cage, kennel, laundry, clothes, hardwood, litter box and more. even use it for small animals like hamsters, rat, and mice cages
  • Safe around kids & pets - trinova understands your pets frequent the spaces where you and your children spend the most time as well. because of this, trinova's pet stain & odor remover contains a formula that leaves surfaces safe for your kids to keep on playing without any worry about harmful chemicals or toxins.
  • 100% satisfaction guarantee - we think you'll love our product, but if you don't just let us know and we'll refund your purchase price!

3. ANGRY ORANGE 24 oz Ready-to-Use Citrus Pet Odor Eliminator Pet Spray - Urine

3
9.1/10 our score

  • Ready to use: no more mixing! use this pet stain remover directly on dog pee, cat urine or solid waste
  • Strong and safe: this pet spray has 2x more odor fighting power. safe to use around your pets and children
  • Fierce & fresh: all-natural & super-powerful cat and dog stain deodorizer
  • Multipurpose deodorizer: works on carpet, tile, wood floors, driveways, litter boxes, grass, pens, and more
  • Urine odor remover solution: our formula smells like fresh oranges because it is made from oranges!

4. ANGRY ORANGE - Best Enzyme Pet Odor Eliminator and Stain Remover to Destroy

4
8.8/10 our score

  • Enzyme activated natural enzymatic bacteria activate instantly to fight stains on contact, destroying unwanted nastiness for up to 80hrs!
  • 100% satisfaction guaranteed angry orange cares about your happiness! if your not happy, well refund your order asap!
  • Safe with a gentle scent safe to use around pets & children. fresh & gentle citrus scent really works furry freshness magic.
  • Our new formula works overtime updated this year! use on carpets, floors, litter boxes, kennels, furniture, and all pet living areas.
  • Destroys even the worst pet odors a nature's miracle, enzymatic powers deodorize and clean your worst urine, feces, or vomit stains.

5. Puracy Natural Laundry Stain Remover, Enzyme-Based Spot Cleaner, Free & Clear, 25 Ounce

5
8.6/10 our score

  • Natural formula is safe for your family, dark colors, delicate fabrics, grey water and septic systems, and the environment, never tested on animals, 100% satisfaction guaranteed, made in the usa!
  • We donate: for every sale, we donate our natural & organic products to children and families that are less fortunate
  • Completely eliminates grass, berries, blood, sweat, oil, tomato sauce, watermelon, red wine, mud, cosmetics, pet accidents, and hundreds of other stains and odors, effective on clothing, linens, carpets, floor mats, dress shirts, bedding, car seats, cloth diapers and other washable fabrics
  • Guaranteed to be the most effective stain remover youve ever used
  • Safely removes any type of stain: natural ingredients, hypoallergenic, gluten-free, non-toxic, non-bleaching, biodegradable, vegan, certified cruelty-free

6. Simple Solution Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X

6
8.3/10 our score

  • Specifically for pet odors and organic stains - safely and quickly removes dog and cat urine, feces, and vomit on carpet, upholstery, bedding, fabric toys, clothing, or other water-safe surfaces in your home
  • Designed for the toughest odors and organic stains- simple solution pet extreme stain and odor remover is three times stonger than our regular formula to eliminate tough dog and cat odors and stains.
  • New patented multi-functional sprayer - now designed with a new patented 3-in-1 nozle sprayer (foam, mist, and stream).
  • Professional strength formula - extreme stain and odor remover is a professional strength pro-bacteria and enzyme formula that breaks down and eliminates stains and odors.

7. Nature’s Miracle P-96992 Advanced Stain and Odor Eliminator Cat, For Severe Cat Messes

7
8.1/10 our score

  • Light fresh scent: cat odor control formula gets your home smelling clean again.
  • For severe cat messes: powerful enzymatic formula works to eliminate tough stains and odors from cat urine, diarrhea, vomit and other bio-based accidents.
  • Discourages resoiling: removes the odor from even the toughest cat messes.
  • Enzymatic formula: continues working as long as any bio-based mess is still present.
  • Safe for pets and home: when used and stored as directed, this formula can be used around your pets.
  • Trusted brand: from the maker of natures miracle products, the pet stain and odor removing brand you trust because it works!

8. Nature's Miracle New Formula Stain & Odor Remover Spray, 32 fl. oz., 32

8
7.8/10 our score

  • Light citrus scent: dog odor control formula gets your home smelling clean again.
  • Safe for pets and home: when used and stored as directed, this formula can be used around your pets.
  • Fast-acting formula clings to surfaces to break down and remove embedded dirt and debris
  • Trusted brand: from the maker of natures miracle products, the pet stain and odor removing brand you trust because it works!
  • Spot stain & odor remover: begins to break down and remove stains immediately on contact.
  • Enzymatic formula: continues working as long as any bio-based mess is still present.

9. BUBBAS Super Strength Commercial Enzyme Cleaner - Pet Odor Eliminator | Enzymatic Stain

9
7.5/10 our score

  • Many uses: our enzyme based stain remover and cleaning solution can be used in all areas of your house, auto, kitchen, bathroom, laundry room and more. use to remove shoe odor, clean auto carpeting stains, use as clothes pretreat for removal of tough set in grass stains. litter box cleaner, or on furniture to remove odor causing bacteria
  • Pet stain and odor miracle: bubba's uses natural dormant bacteria that become active upon hitting that strong smelling cat pee, billions of enzymes destroy stains down to the carpet pad. competitors use active bacteria that die off and lose effect
  • Best professional grade cleaning solution: scientifically formulated to be more potent than other pet odor enzyme cleaners for your flooring, upholstery, area rugs and carpets, yet safe to use around kids and pets. permanently destroys pet enzyme odors and stains
  • Carpet & rug institute certified: our pet pee cleaner and enzymatic odor remover is a top rated pet stain & odor miracle. don't be disappointed by other brands pet cleaner sprays. try bubbas pet enzyme treatment cleaner instead
  • Satisfaction guaranteed: other pet odor enzyme sprays use active bacteria that are ineffective soon after you buy them. bubba's dormant bacteria formula is the best premium deep cleaning stain and pet urine enzyme carpet cleaner or your money back

10. Woolite Advanced Pet Stain & Odor Remover + Sanitize, 2618, 22oz

10
7.2/10 our score

  • Cleans, sanitizes, and deodorizes in one easy step.
  • One sprayer is included with two-packs. please keep your sprayer and reuse it for the second bottle (simply remove the sprayer from the first bottle and apply to the second). we do this with the intention to maintain the ability to supply our valued customers during seasons of high demand while helping reduce the use of plastic by reusing those sprayers. thank you for y...
  • Leaves carpets sanitized for children and pets when used as directed.
  • Permanently removes tough pet stains.
  • Kills 99. 9% of bacteria.
  • Penetrates to eliminate pet odors at their source.

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